Results 121 to 130 of about 578,588 (318)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Longitudinal optical binding [PDF]
, 2008 Longitudinal optical binding refers to the light induced self organisation of micro particles in one dimension. In this thesis I will present experimental and theoretical studies of the separation between two dielectric spheres in a counter-propagating
Metzger, Nikolaus K.
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
IEEE Access, 2019 Mutually complementary bases are crucial to secure quantum key distribution (QKD). By aiming at free-space QKD with use of spatially structured photons, the effect of turbulence on the mutual unbiasedness of two complementary bases relevant to photonic ...
Chunyi Chen, Huamin Yang
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Optical high-speed 3D metrology in harsh environments: Recording structural data of railway lines [PDF]
, 2022 S.296-306This paper reports measurement results and some design details of railway measurement systems based on optical principles. The quality of railway lines is crucial for reliability and safety and therefore to be controlled regularly.
Wölfelschneider, H. +5 more
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Unmanned Aerial Vehicles (UAVs) in Landslide Investigation and Monitoring: A Review
DronesOver the past decade, Unmanned Aerial Vehicles (UAVs) have emerged as essential tools for landslide studies, particularly in on-site investigations.
Jianwei Sun +3 more
doaj +1 more source
Optical Measurement of Ligament Strain: Opportunities and Limitations for Intraoperative Application. [PDF]
Sensors (Basel), 2023 Marx C, Wulff P, Fink C, Baumgarten D.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source