Results 51 to 60 of about 267,024 (268)

Efficient Frequency-Domain Block Equalization for Mode-Division Multiplexing Systems

open access: yesPhotonics
In this paper, an adaptive frequency-domain block equalizer (FDBE) implementing the adaptive moment estimation (Adam) algorithm is proposed for mode-division multiplexing (MDM) optical fiber communication systems. By packing all frequency components into
Yifan Shen   +4 more
doaj   +1 more source

Twelve-Wavelength-Switchable Thulium-Doped Fiber Laser With a Multimode Fiber Bragg Grating

open access: yesIEEE Photonics Journal, 2021
In this article, a precisely controlled, switchable thulium-doped fiber laser (TDFL) with high optical signal-to-noise ratio (OSNR) is proposed and demonstrated.
Qi Qin   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A Tutorial on Optical Networks [PDF]

open access: yes, 2002
In this half-day tutorial, we present the current state-of-the-art in optical networks. We begin by discussing the various optical devices used in optical networks. Then, we present wavelength-routed networks, which is currently the dominant architecture for optical networks.
George N. Rouskas, Harry G. Perros
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Joint Modulation Format Identification and Frequency Offset Estimation Based on Superimposed LFM Signal and FrFT

open access: yesIEEE Photonics Journal, 2019
We propose a novel technique for joint modulation format identification and frequency offset (FO) estimation. The linear frequency modulation signal which is obtained by a direct current signal and Fractional Fourier Transform (FrFT) is superimposed on ...
Yuxiao Guo   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

L-Band Erbium-Doped Fiber Optimization and Transmission Investigation

open access: yesPhotonics
The optical spectrum resource in the C-band has been used up due to dense wavelength division multiplexing (DWDM). Because of devices’ compatibility with both the C-band and the L-band, the L-band is a good choice for further capacity expansion ...
Kaihua Hu   +7 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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