Results 71 to 80 of about 331,774 (318)

Stable Multi-Wavelength Thulium-Doped Fiber Laser With Two Cascaded Single-Mode-Four-Mode-Single-Mode Fiber Interferometers

IEEE Access, 2021
We propose and experimentally demonstrate a multi-wavelength thulium-doped fiber laser using two cascaded single-mode-four-mode-single-mode (SFS) fiber interferometers and a 150-m-long highly nonlinear fiber.
Ying Guo, Fengping Yan, Ting Feng, Qi Qin, Luna Zhang, Biao Guan, Wenguo Han, Zhuoya Bai, Hong Zhou, Yuping Suo   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Twelve-Wavelength-Switchable Thulium-Doped Fiber Laser With a Multimode Fiber Bragg Grating

IEEE Photonics Journal, 2021
In this article, a precisely controlled, switchable thulium-doped fiber laser (TDFL) with high optical signal-to-noise ratio (OSNR) is proposed and demonstrated.
Qi Qin, Fengping Yan, Yan Liu, Zhenchen Cui, Cheng Dan, Chenhao Yu, Youchao Jiang, Yuping Suo, Hong Zhou, Ting Feng   +9 more
doaj   +1 more source

Optical Neural Networks

CoRR, 2018
We develop a novel optical neural network (ONN) framework which introduces a degree of scalar invariance to image classification estima- tion. Taking a hint from the human eye, which has higher resolution near the center of the retina, images are broken out into multiple levels of varying zoom based on a focal point.
Grant Fennessy, Yevgeniy Vorobeychik
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Efficient Frequency-Domain Block Equalization for Mode-Division Multiplexing Systems

Photonics
In this paper, an adaptive frequency-domain block equalizer (FDBE) implementing the adaptive moment estimation (Adam) algorithm is proposed for mode-division multiplexing (MDM) optical fiber communication systems. By packing all frequency components into
Yifan Shen, Jianyong Zhang, Shuchao Mi, Guofang Fan, Muguang Wang   +4 more
doaj   +1 more source

Joint Modulation Format Identification and Frequency Offset Estimation Based on Superimposed LFM Signal and FrFT

IEEE Photonics Journal, 2019
We propose a novel technique for joint modulation format identification and frequency offset (FO) estimation. The linear frequency modulation signal which is obtained by a direct current signal and Fractional Fourier Transform (FrFT) is superimposed on ...
Yuxiao Guo, Muguang Wang, Yaozu Li, Hongqian Mu, Beilei Wu, Yan Liu, Fengping Yan   +6 more
doaj   +1 more source

Optical Machine Learning Using Time-Lens Deep Neural NetWorks

, 2021
As a high-throughput data analysis technique, photon time stretching (PTS) is widely used in the monitoring of rare events such as cancer cells, rough waves, and the study of electronic and optical transient dynamics.
Caiyun Li, Yange Liu, Jian Zhao, Zhi Wang, Huiyi Guo, Congcong Liu, Luhe Zhang, Jiangyong He, Kaiyan Zhu, Mengjie Zhou, Longfei Zhu   +10 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source