Results 81 to 90 of about 331,774 (318)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

L-Band Erbium-Doped Fiber Optimization and Transmission Investigation

Photonics
The optical spectrum resource in the C-band has been used up due to dense wavelength division multiplexing (DWDM). Because of devices’ compatibility with both the C-band and the L-band, the L-band is a good choice for further capacity expansion ...
Kaihua Hu, Li Pei, Jianshuai Wang, Zhouyi Hu, Wenxuan Xu, Long Zhang, Jing Li, Li Zhong   +7 more
doaj   +1 more source

Network Programmability and Automation in Optical Networks [PDF]

, 2020
During last years, novel protocols and data models are arising to control and monitor optical network equipment. These protocols enable network programmability and automation by ful lling the vision introduced by Software De ned Networking (SDN). This paper o ers an overview and hands-on experience on programming the necessary tools to control and ...
Ricard Vilalta, Ramon Casellas, Ricardo Martínez 0001, Raul Muñoz 0001   +3 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Accurate determination of terahertz optical constants by vector network analyzer of Fabry-Perot response [PDF]

, 2013
This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.38.005438.
Wang, X, Sun, W, Yang, B, Donnan, R, Zhang, Y   +4 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Spoof Surface Plasmon Polaritons Fed Frequency-Scanning Open-Loop Antenna Arrays

IEEE Access, 2019
Spoof surface plasmon polaritons (SSPPs) fed open-loop elements without a metallic ground plane are investigated for the SSPPs-based antenna design. By employing a straight SSPPs section close to the open end of the loop as the feed, the one-wavelength ...
Di Cao, Yujian Li, Junhong Wang
doaj   +1 more source

Creating nuclear spin entanglement using an optical degree of freedom

, 2014
Funding: Marie Curie Early Stage Training network QIPEST (Grant No. MESTCT-2005-020505), the EPSRC through QIP IRC (Grant Nos. GR/S82176/01 and GR/S15808/01), the National Research Foundation and Ministry of Education, Singapore, the DAAD (German ...
Schaffry, Marcus, Lovett, Brendon W., Gauger, Erik M.   +2 more
core   +1 more source