Results 91 to 100 of about 579,349 (293)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Subsystems for future access networks [PDF]

, 2010
Current evolution and tendencies of Telecom Networks in general and more specifically optical Metro and Access Networks and their convergence are reported. Based on this evolution, a set of research lines are foreseen regarding subsystems and devices as:
Avramopoulos, Hercules, Chanclou, Philippe, Erasme, Didier, Kazmierski, Christophe, Kehayas, Efstratios, Langer, Klaus-Dieter, Lazaro, Jose A, Monroy, Idelfonso T, Poggiolini, Pierluigi, Prat, Josep, Qiu, Xing-Zhi, Sambaraju, Rakesh, Soila, Risto, Tangdiongga, Eduward, Teixeira, Antonio, Tomkos, Ioannis   +15 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optical beam forming for phased-array antennas [PDF]

, 2007
The activities of the Telecommunication Engineering (TE) group span the communications spectrum from copper cables, optical fibres, microwaves, radio and electromagnetic compatibility.
Borreman, A., Etten, W. van, Heideman, R.G., Marpaung, D.A.I., Meijerink, A., Roeloffzen, C.G.H., Zhuang, L.   +6 more
core   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

High Sensitivity Refractometer Based on TiO2-Coated Adiabatic Tapered Optical Fiber via ALD Technology

Sensors, 2016
Atomic layer deposition (ALD) technology is introduced to fabricate a high sensitivity refractometer based on an adiabatic tapered optical fiber. Different thicknesses of titanium dioxide (TiO2) nanofilm were coated around the tapered fiber precisely and
Shan Zhu, Fufei Pang, Sujuan Huang, Fang Zou, Qiang Guo, Jianxiang Wen, Tingyun Wang   +6 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

System Performance Optimization of Frequency-Swept Pump-Based Rectangular Brillouin Optical Filter

IEEE Photonics Journal, 2017
In this paper, we realize a series of 2-GHz wide rectangular optical filters based on the stimulated Brillouin scattering (SBS) effect in optical fiber with a frequency-swept pump and gain feedback compensation scheme.
M. Shi, L. Yi, W. Wei, G. Pu, W. Hu
doaj   +1 more source

Optically powered fiber networks

Optics Express, 2008
Optically powered networks are demonstrated. Heterogeneous subscribers having widely varying needs with respect to power and band-width can be effectively controlled and optically supplied by a central of-fice. The success of the scheme relies both on power-efficient innovative hardware and on a novel low-energy medium access control protocol.
Freude, W., Leuthold, J., Röger, M., Böttger, G., Dreschmann, M., Huebner, M., Klamouris, C., Becker, J., Bett, A.   +8 more
openaire   +2 more sources