Results 71 to 80 of about 584,260 (294)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spectral Efficiency Improved 2D-PAM8 Trellis Coded Modulation for Short Reach Optical System

IEEE Photonics Journal, 2017
This paper proposes and demonstrates a 31.25 Gbps two-dimensional eight level pulse amplitude modulation with trellis coded modulation (2D-PAM8-TCM) transmission in intensity modulation and direct detection based short reach system. In this system,
Yan Fu, Meihua Bi, Da Feng, Xin Miao, Hao He, Weisheng Hu   +5 more
doaj   +1 more source

Optically addressing single rare-earth ions in a nanophotonic cavity [PDF]

, 2018
We demonstrate optical probing of spectrally resolved single Nd rare-earth ions in yttrium orthovanadate. The ions are coupled to a photonic crystal resonator and show strong enhancement of the optical emission rate via the Purcell effect, resulting in ...
Bartholomew, John G., Beyer, Andrew D., Craiciu, Ioana, Faraon, Andrei, Kindem, Jonathan M., Marsili, Francesco, Nam, Sae Woo, Rochman, Jake, Shaw, Matthew D., Verma, Varun, Zhong, Tian   +10 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Anti-resonant acoustic waveguides enabled tailorable Brillouin scattering on chip

Nature Communications
Empowering independent control of optical and acoustic modes and enhancing the photon-phonon interaction, integrated photonics boosts the advancements of on-chip stimulated Brillouin scattering (SBS). However, achieving acoustic waveguides with low loss,
Peng Lei, Mingyu Xu, Yunhui Bai, Zhangyuan Chen, Xiaopeng Xie   +4 more
doaj   +1 more source

OLS-Based RBF Neural Network for Nonlinear and Linear Impairments Compensation in the CO-OFDM System

IEEE Photonics Journal, 2018
For the first time, we propose and experimentally verify a novel low-complexity orthogonal least square (OLS) based radial basis function (RBF) neural network (NN) nonlinear equalizer for high-speed coherent optical orthogonal frequency division ...
Ling Liu, Meihua Bi, Shilin Xiao, Jiafei Fang, Tiancheng Huang, Weisheng Hu   +5 more
doaj   +1 more source

Topological protection of continuous frequency entangled biphoton states

Nanophotonics, 2021
Topological quantum optics that manipulates the topological protection of quantum states has attracted special interests in recent years. Here we demonstrate valley photonic crystals implementing topologically protected transport of the continuous ...
Jiang Zhen, Ding Yizhou, Xi Chaoxiang, He Guangqiang, Jiang Chun   +4 more
doaj   +1 more source

Optical Soliton Neural Networks

, 2023
The chapter describes the realization of photonic integrated circuits based on photorefractive solitonic waveguides. In particular, it has been shown that X-junctions formed by soliton waveguides can learn information by switching their state. X junctions can perform both supervised and unsupervised learning.
Eugenio Fazio, Alessandro Bile, Hamed Tari   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source