Results 51 to 60 of about 7,172 (218)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Anti-resonant acoustic waveguides enabled tailorable Brillouin scattering on chip

Nature Communications
Empowering independent control of optical and acoustic modes and enhancing the photon-phonon interaction, integrated photonics boosts the advancements of on-chip stimulated Brillouin scattering (SBS). However, achieving acoustic waveguides with low loss,
Peng Lei, Mingyu Xu, Yunhui Bai, Zhangyuan Chen, Xiaopeng Xie   +4 more
doaj   +1 more source

OLS-Based RBF Neural Network for Nonlinear and Linear Impairments Compensation in the CO-OFDM System

IEEE Photonics Journal, 2018
For the first time, we propose and experimentally verify a novel low-complexity orthogonal least square (OLS) based radial basis function (RBF) neural network (NN) nonlinear equalizer for high-speed coherent optical orthogonal frequency division ...
Ling Liu, Meihua Bi, Shilin Xiao, Jiafei Fang, Tiancheng Huang, Weisheng Hu   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Optimization for UAV-assisted simultaneous transmission and reception communications in the existence of malicious jammers

Security and Safety
In this paper, we study an unmanned aerial vehicle (UAV)-assisted communication system, where the UAV is dispatched to implement simultaneous transmission and reception (STR) in the existence of multiple malicious jammers.
Huang Zhiyu, Liu Shuzhen, Sheng Zhichao, Yu Hongwen, Masaracchia Antonino   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Improved Power Budget of 112 Gb/s/$\lambda$ Intra-Datacentre Links Using a Split-Carrier Transmitter Architecture

IEEE Photonics Journal, 2019
A split-carrier transmitter is proposed to improve loss budget for short distance 100 G-per-wavelength intra-datacentre links. By applying a low-complexity hardware modification to the transmitter, the proposed architecture reduces transmitter ...
Thomas Gerard, Zhixin Liu, M. Sezer Erkilinc, Lidia Galdino, Polina Bayvel, Benn Thomsen, Domanic Lavery   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source