Results 61 to 70 of about 143,606 (219)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

System Performance Optimization of Frequency-Swept Pump-Based Rectangular Brillouin Optical Filter

IEEE Photonics Journal, 2017
In this paper, we realize a series of 2-GHz wide rectangular optical filters based on the stimulated Brillouin scattering (SBS) effect in optical fiber with a frequency-swept pump and gain feedback compensation scheme.
M. Shi, L. Yi, W. Wei, G. Pu, W. Hu
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

High-coherence parallelization in integrated photonics

Nature Communications
Coherent optics has profoundly impacted diverse applications ranging from communications, LiDAR to quantum computations. However, developing coherent systems in integrated photonics comes at great expense in hardware integration and energy efficiency ...
Xuguang Zhang, Zixuan Zhou, Yijun Guo, Minxue Zhuang, Warren Jin, Bitao Shen, Yujun Chen, Jiahui Huang, Zihan Tao, Ming Jin, Ruixuan Chen, Zhangfeng Ge, Zhou Fang, Ning Zhang, Yadong Liu, Pengfei Cai, Weiwei Hu, Haowen Shu, Dong Pan, John E. Bowers, Xingjun Wang, Lin Chang   +21 more
doaj   +1 more source

Significantly High Modulation Efficiency of Compact Graphene Modulator Based on Silicon Waveguide

Scientific Reports, 2018
We theoretically and experimentally demonstrate a significantly large modulation efficiency of a compact graphene modulator based on a silicon waveguide using the electro refractive effect of graphene.
Haowen Shu, Zhaotang Su, Le Huang, Zhennan Wu, Xingjun Wang, Zhiyong Zhang, Zhiping Zhou   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Flexible Baseband-Unit Aggregation Enabled by Reconfigurable Multi-IF Over WDM Fronthaul

IEEE Photonics Journal, 2018
In cloud-radio access network, baseband-unit (BBU) aggregation schemes have been intensively discussed to improve the efficiency of resources in light traffic times.
Haiyun Xin, Hao He, Kuo Zhang, Syed Baqar Hussain, Weisheng Hu   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source