Results 41 to 50 of about 7,172 (218)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
IEEE Photonics Journal, 2017 In this paper, the performance of polar code in high-speed coherent optical orthogonal frequency division multiplexing (CO-OFDM) system with nonlinear and linear impairments is comprehensively investigated for the first time.
Ling Liu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
IEEE Photonics Journal, 2017 In this paper, we propose and experimentally demonstrate an optical self-interference cancellation (OSIC) system with baseband predistortion for wideband over-the-air in-band full-duplex (IBFD) communication.
Yunhao Zhang +5 more
doaj +1 more source
A Tutorial on Optical Networks [PDF]
, 2002 In this half-day tutorial, we present the current state-of-the-art in optical networks. We begin by discussing the various optical devices used in optical networks. Then, we present wavelength-routed networks, which is currently the dominant architecture for optical networks.
George N. Rouskas, Harry G. Perros
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Metamaterial-enabled arbitrary on-chip spatial mode manipulation
Light: Science & Applications, 2022 On-chip spatial mode operation, represented as mode-division multiplexing (MDM), can support high-capacity data communications and promise superior performance in various systems and numerous applications from optical sensing to nonlinear and quantum ...
Jinlong Xiang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Spectral Efficiency Improved 2D-PAM8 Trellis Coded Modulation for Short Reach Optical System
IEEE Photonics Journal, 2017 This paper proposes and demonstrates a 31.25 Gbps two-dimensional eight level pulse amplitude modulation with trellis coded modulation (2D-PAM8-TCM) transmission in intensity modulation and direct detection based short reach system. In this system,
Yan Fu +5 more
doaj +1 more source