Results 71 to 80 of about 380,624 (313)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Design of Optical Tunnel Switching Networks for Big Data Applications

open access: yesApplied Sciences, 2020
In this paper, we proposed large-scale optical tunnel switching networks based on the Torus topology network with WSS (Wavelength Selective Switch) for future big data applications.
Yuh-Jiuh Cheng   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Switching of three-dimensional optical cages using spatial coherence engineering

open access: yesAPL Photonics
Precisely capturing and manipulating microparticles is the key to exploring microscopic mysteries. Optical tweezers play a crucial role in facilitating these tasks. However, existing optical tweezers are limited by their dependence on specific beam modes,
Ying Xu   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Organization of the channel-switching process in parallel computer systems based on a matrix optical switch [PDF]

open access: yes
After a classification and analysis of electronic and optoelectronic switching devices, the design principles and structure of a matrix optical switch is described.
Golomidov, Y. V.   +3 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Performance-Improved Broadcast-and-Select Optical Switch Module Based on EAM-Gate Array

open access: yesIEEE Photonics Journal, 2016
Performance improvement of a broadcast-and-select (B&S) optical switch based on an electro-absorption modulator (EAM)-gate array is presented.
Y. Muranaka   +4 more
doaj   +1 more source

Equivalent random analysis of a buffered optical switch with general interarrival times [PDF]

open access: yes, 2009
We propose an approximate analytic model of an optical switch with fibre delay lines and wavelength converters by employing Equivalent Random Theory. General arrival traffic is modelled by means of Gamma-distributed interarrival times.
Barry, Liam P.   +2 more
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

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