Results 91 to 100 of about 2,880 (253)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

open access: yesAdvanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu   +7 more
wiley   +1 more source

Dosimetry for low-energy electron beam applications at Fraunhofer FEP

open access: yesNukleonika
Accelerating electrons to achieve chemical and biological effects is a well-established competence of Fraunhofer FEP. Today, there is a large variety of low-energy electron beam applications with a broad range of absorbed doses, e.g.
Teichmann Tobias   +9 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang   +19 more
wiley   +1 more source

Sedimentology and chronology of unconsolidated alluvial fans of the Quadrilátero Ferrífero (Central Brazil): implications for landscape dynamics in the Late Quaternary

open access: yesRevista Brasileira de Geomorfologia
This paper identifies and discusses the paleoenvironmental characteristics of the Quadrilátero Ferrífero based on studies of unconsolidated alluvial fans and the chronological organization of their respective sedimentary facies. These alluvial fans were
Fabrício Antonio Lopes   +3 more
doaj   +1 more source

Dating the megalithic culture of laos: Radiocarbon, optically stimulated luminescence and U/Pb zircon results. [PDF]

open access: yesPLoS One, 2021
Shewan L   +11 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

open access: yesAdvanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green   +15 more
wiley   +1 more source

Nanostructured carbon-doped α-Al2O3 microspheres: Scalable synthesis and luminescence properties

open access: yesNext Materials
This study presents a novel method of synthesizing alumina doped with carbon through the scalable spray drying process. In the first step nanostructured Al(OH)3 microspheres are synthesized by spray drying with excellent flowability, narrow size ...
Pankaj Singh   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy