Results 101 to 110 of about 3,277,431 (296)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Computationally-Efficient Data-Driven Safe Optimal Algorithm Through Control Merging

IEEE Open Journal of Control Systems
This article presents a proactive approach to resolving the conflict between safety and optimality for continuous-time (CT) safety-critical systems with unknown dynamics.
Marjan Khaledi, Bahare Kiumarsi
doaj   +1 more source

Laplace transforms and the American straddle

Journal of Applied Mathematics, 2002
We address the pricing of American straddle options. We use partial Laplace transform techniques due to Evans et al. (1950) to derive a pair of integral equations giving the locations of the optimal exercise boundaries for an American straddle option ...
G. Alobaidi, R. Mallier
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Control and characterization of individual grains and grain boundaries in graphene grown by chemical vapour deposition [PDF]

, 2011
The strong interest in graphene has motivated the scalable production of high-quality graphene and graphene devices. As the large-scale graphene films synthesized so far are typically polycrystalline, it is important to characterize and control grain ...
Pei, Shin-Shem, Yong P. Chen, Peng, Peng, Deepak Pandey, Zhihua Su, Jifa Tian, Chung, Ting Fung, Liu, Zhihong, Jiming Bao, Luis A. Jauregui, Pandey, Deepak, Nathan P. Guisinger, Cao, Helin, Chen, Yong P., Qingkai Yu, Guisinger, Nathan P., Helin Cao, Dongguang Wei, Wu, Wei, Bao, Jiming, Yu, Qingkai, Ting Fung Chung, Peng Peng, Wei, Dongguang, Tian, Jifa, Wei Wu, Eric A. Stach, Colby, Robert, Shin-Shem Pei, Jauregui, Luis A., Robert Colby, Su, Zhihua, Stach, Eric A., Zhihong Liu   +33 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Managing across knowledge boundaries

, 2017
This chapter discusses the implications of knowledge specialization in relation to five types of knowledge boundaries (individual, domain-specific, task-oriented, spatial, and temporal), and mechanisms that potentially could be used to bridge these ...
Tell, Fredrik,
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

OPTIMAL CONTROL OF A THERMALLY STRESSED STATE FOR A BODY UNDER SPECIFIED STRESSES

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2006
The paper considers new problems concerned with optimal control of a thermally stressed state for a body with specified stresses on its boundaries.
I.V. Sergienko, V.S. Deineka
doaj  

PENENTUAN TITIK-TITIK BATAS OPTIMUM STRATA PADA PENARIKAN CONTOH ACAK BERLAPIS DENGAN PEMROGRAMAN DINAMIK (Kasus : Pengeluaran per Kapita Propinsi Jawa Timur Tahun 2008)

Al-Jabar, 2015
Optimum stratification is the method of choosing the best boundaries that make strata internally homogeneous, given some sample allocation. In order to make the strata internally homogenous, the strata should be constructed in such a way that the strata ...
Mahyudi Mahyudi
doaj   +1 more source