Results 91 to 100 of about 3,277,431 (296)

On the boundaries of optimally designed elastoplastic structures [PDF]

open access: yesComputer Research and Modeling, 2017
This paper studies minimum volume elastoplastic bodies. One part of the boundary of every reviewed body is fixed to the same space points while stresses are set for the remaining part of the boundary surface (loaded surface). The shape of the loaded surface can change in space but the limit load factor calculated based on the assumption that the bodies
openaire   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

No boundaries : International Art Colony, Bald Head Island, NC, USA, November 6-20, 1998

open access: yes, 2008
"No boundaries" was born from the passion of three Wilmington artists--Paula Toll, Gayle Tustin, and Dick Roberts"--(p. [1]) [introduction by Anthony F.
International Art Colony (1st : 1998 : Bald Head Island, N.C.)
core   +3 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Impact of spatial averaging on radar reflectivity at internal snowpack layer boundaries

open access: yesJournal of Glaciology, 2016
Microwave radar amplitude within a snowpack can be strongly influenced by spatial variability of internal layer boundaries. We quantify the impact of spatial averaging of snow stratigraphy and physical snowpack properties on surface scattering from near ...
N. RUTTER   +4 more
doaj   +1 more source

Beyond the Boundaries of Proximal Policy Optimization

open access: yesCoRR
Proximal policy optimization (PPO) is a widely-used algorithm for on-policy reinforcement learning. This work offers an alternative perspective of PPO, in which it is decomposed into the inner-loop estimation of update vectors, and the outer-loop application of updates using gradient ascent with unity learning rate.
Charlie B. Tan   +4 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Resolve Ties Method for Re-establishing Fit for Purpose Survey Boundaries

open access: yesAfrican Journal on Land Policy and Geospatial Sciences
Countries including Uganda adopted Fit-for-Purpose (FFP) Land Administration as a viable approach towards achieving full coverage of land registration aimed at empowering communities to secure land rights and enhance land management.
Ismail Wadembere
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial linear network Voronoi analysis to quantify accessibility of police stations in South Africa

open access: yesCrime Science
This study quantifies the overlap between existing police precinct boundaries and theoretically optimal boundaries derived from Voronoi diagrams based on Euclidean and network distances. Accessibility refers to how easily an individual can reach a police
Arthur Antonio   +3 more
doaj   +1 more source

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