Results 71 to 80 of about 3,277,431 (296)

Sharp interfaces in p+-AlGaAs/n-GaAs epitaxial structures obtained by MOCVD

open access: yesTekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2014
The complexity of forming sharp and high-quality boundaries in p+AlGaAs/n-GaAs systems by MOCVD method is caused by differing on 80–120°С optimal crystallization temperature of GaAs layers and n-AlGaAs solid solutions.
N. M. Vakiv   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Determining the extent and frequency of on-site monitoring: a bayesian risk-based approach

open access: yesBMC Medical Research Methodology
Background On-site monitoring is a crucial component of quality control in clinical trials. However, many cast doubt on its cost-effectiveness due to various issues, such as a lack of monitoring focus that could assist in prioritizing limited resources ...
Longshen Xie   +3 more
doaj   +1 more source

Boundary cost optimization for Alternate Test [PDF]

open access: yes2015 20th IEEE European Test Symposium (ETS), 2015
Ministerio de Economia y Competitividad TEC2011 ...
openaire   +5 more sources

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Provable Benefit of Mixup for Finding Optimal Decision Boundaries [PDF]

open access: yes, 2023
We investigate how pair-wise data augmentation techniques like Mixup affect the sample complexity of finding optimal decision boundaries in a binary linear classification problem.
Oh, Junsoo, Yun, Chulhee
core   +2 more sources

Optimal policy for value-based decision-making

open access: yesNature Communications, 2016
Drift diffusion models (DDM) are fundamental to our understanding of perceptual decision-making. Here, the authors show that DDM can implement optimal choice strategies in value-based decisions but require sufficient knowledge of reward contingencies and
Satohiro Tajima   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Optimal boundaries for decisions [PDF]

open access: yes
In this paper we state and prove some new results about the optimal boundaries. These boundaries (also called Pareto boundaries or efficiency boundaries or maximal/minimal boundaries) are of increasing importance in the applications to Decision Theory ...
Carfì, David
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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