Results 61 to 70 of about 3,277,431 (296)
OptGS: An R Package for Finding Near-Optimal Group-Sequential Designs
Journal of Statistical Software, 2015 A group-sequential clinical trial design is one in which interim analyses of the data are conducted after groups of patients are recruited. After each interim analysis, the trial may stop early if the evidence so far shows the new treatment is ...
James Wason
doaj +1 more source
Optimal PID Controller Design Based on PSO-RBFNN for Wind Turbine Systems
Energies, 2014 A strategy was proposed to determine the optimal operating point for the proportional-integral-derivative (PID) controller of a wind turbine, and identify the stability regions in the parameter space.
Jau-Woei Perng +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Compliance with planetary boundaries in international law
, 2021 Planetary and legal boundaries can only be effective if they are observed, respected and complied with. In Chapter 10, Jonas Ebbesson addresses the critical issue of compliance with planetary boundaries in international law.
Ebbesson, Jonas,, Jonas Ebbesson
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
An optimal boundary to quadtree conversion algorithm [PDF]
CVGIP: Image Understanding, 1991 Summary: An algorithm is presented for converting a boundary representation for an image to its region quadtree representation. Our algorithm is designed for operation on the linear quadtree representation, although it can easily be modified for the traditional pointer-based quadtree representation.
Mark R. Lattanzi, Clifford A. Shaffer
openaire +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Importance of low-angle grain boundaries in YBa2Cu3O7-delta coated conductors [PDF]
, 2008 Over the past ten years the perception of grain boundaries in YBa2Cu3O7−δ conductors has changed greatly. They are now not a problem to be eliminated, but an inevitable and potentially favourable part of the material.
N A Rutter, J H Durrell
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