Results 111 to 120 of about 356,969 (310)

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A New Algorithm to Optimize Maximal Information Coefficient

PLOS ONE, 2016
The maximal information coefficient (MIC) captures dependences between paired variables, including both functional and non-functional relationships. In this paper, we develop a new method, ChiMIC, to calculate the MIC values. The ChiMIC algorithm uses the chi-square test to terminate grid optimization and then removes the restriction of maximal grid ...
Yuan Chen, Ying Zeng, Feng Luo, Zheming Yuan   +3 more
openaire   +4 more sources

A simplified method to get the optimal coefficients of lagrange-constrained polynomial interpolators

, 2010
This paper presents a simplified algorithm to get the optimal coefficients of Lagrange-constrained polynomial interpolators. The Lagrange-constrained interpolators are widely used in communication systems.
J Xiong (6097910), R Miao (13514326), L Gui (13621342), B Liu (7688321)   +3 more
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Optimal designs for estimating individual coefficients in Fourier regression models [PDF]

, 2001
In the common trigonometric regression model we investigate the optimal design problem for the estimation of the individual coefficients, where the explanatory variable varies in the interval [-a ,a] ; 0 < a < t.
Dette, Holger, Melas, Viatcheslav B.
core  

The comparison of coefficients, optimal candidates and reconstruction.

, 2016
The top is the coefficients of our method versus unconstrained, spars coding and sparse counting regularization, respectively. The bottom is the optimal candidates and reconstruction results by using unconstrained, sparse coding, sparse counting and our ...
Yu Cai (112178), Zhixun Su (3589973), Risheng Liu (3589979), Xiaoke Shang (3589976), Yiyang Wang (291591), Jing Wang (1228470)   +5 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

OPTIMAL TARGETING OF CREP TO IMPROVE WATER QUALITY: DETERMINING LAND RENTAL OFFERS WITH ENDOGENOUS SEDIMENT DEPOSITION COEFFICIENTS

An integrated watershed management framework that combines detailed spatial biophysical attributes of land with a hydrologic model and an economic model is developed to study the cost-effective enrollment of land in the Conservation Reserve Enhancement ...
Yang, Wanhong, Farnsworth, Richard L., Onal, Hayri, Khanna, Madhu   +3 more
core  

Stochastic optimal control problem for switching systems with constraints

, 2017
WOS: 000405077500012This paper provides necessary conditions of optimality, in the form of a maximum principle, for optimal control problems of switching systems.
Aghayeva, Charkaz
core   +1 more source