Results 41 to 50 of about 2,996,602 (316)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Cooperative Communication in Cognitive Radio Networks under Asymmetric Information: A Contract-Theory Based Approach

open access: yesInternational Journal of Distributed Sensor Networks, 2015
By exploiting the spatial diversity of multiple wireless nodes, cooperative communication technique is a promising technique for spectrum sharing to improve spectrum efficiency.
Nan Zhao, Minghu Wu, Wei Xiong, Cong Liu
doaj   +1 more source

Sustainable and Optimal “Uniqueness” Contract in Public-Private Partnership Projects of Transportation Infrastructure

open access: yesDiscrete Dynamics in Nature and Society, 2020
To control the “uniqueness” risk in Public-Private Partnership (PPP) projects of transportation infrastructure, we design a simplified “uniqueness” contract model by incorporating the impact of the initial investment which is based on the Bertrand model.
Yingjun Zhu, Zhitong Gao, Ruihai Li
doaj   +1 more source

On and Off Contract Remedies [PDF]

open access: yes, 2009
A party dissatisfied with the contractual performance of a counterparty is typically able to pursue a variety of legal recourses. Within this apparent variety lurk two fundamental alternatives.
Stremitzer, Alexander, Brooks, Richard
core   +1 more source

Collateralized Debt as the Optimal Contract [PDF]

open access: yesSSRN Electronic Journal, 1991
In a simple risk-sharing environment with ex post private information, conditions are found under which a collateralized debt contract is the optimal allocation. The critical condition for optimality is that the borrower values the collateral good more highly than does the lender; otherwise the optimal contract does not resemble debt.
openaire   +2 more sources

Optimality of Contraction-Driven Crawling [PDF]

open access: yesPhysical Review Letters, 2014
We study a model of cell motility where the condition of optimal trade-off between performance and metabolic cost can be made precise. In this model a steadily crawling fragment is represented by a layer of active gel placed on a frictional surface and driven by contraction only.
Recho, P.   +2 more
openaire   +3 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Efficient Favouritism with Status Incentives: A Moral-Hazard Game of Delegation and Recognition

open access: yesGames
This paper studies the interaction between status incentives and organizational design in a two-agent moral hazard framework with limited liability.
Swapnendu Banerjee   +2 more
doaj   +1 more source

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