Results 51 to 60 of about 601,863 (315)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
IEEE Access, 2021 We propose an intertemporal inventory decision model under demand uncertainty and retail competition. Facing the fact that different firms may have different intertemporal inventory capabilities, the paper introduces two retailers and assumes only one ...
Jianhu Cai +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Corporate insurance design with multiple risks and moral hazard [PDF]
, 2008 The paper provides novel insights on the effect of a firm’s risk management objective on the optimal design of risk transfer instruments. I analyze the interrelation between the structure of the optimal insurance contract and the firm’s objective to ...
Laux, Christian
core
Optimal Contracting and the Organization of Knowledge [PDF]
The Review of Economic Studies, 2014 We study contractual arrangements that support an efficient use of time in a knowledge-intensive economy in which agents endogenously specialize in either production or consulting. The resulting market for advice is plagued by informational problems, since both the difficulty of the questions posed to consultants and the knowledge of those consultants ...
William Fuchs, Luis Garicano, Luis Rayo
openaire +3 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Cleaner Logistics and Supply ChainApplied model research is an important approach to low-carbon supply chain optimization, and the key of model optimization is the game and contract selection among the participants.
Longlong Zhang, Peng Liu
doaj +1 more source
An Optimal Weekly Operation Strategy for Power Systems with Renewable Energy
Zhongguo dianli, 2020 In order to coordinate the completion of monthly contract electricity quantity, an optimal weekly operation model for multi-source hybrid power system including wind, photovoltaic, cascade hydropower and thermal power is established and analyzed in this ...
Shuqiang ZHAO +3 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source