Results 111 to 120 of about 1,957,614 (317)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Advances in Pseudospectral Methods for Optimal Control [PDF]

open access: yes, 2008
The article of record as published may be located at http://dx.doi.org/10.2514/6.2008-7309Recently, the Legendre Pseudospectral (PS) method migrated from theory to fight application onboard the International Space Station for performing a finite-horizon,
Fariba Fahroo   +3 more
core   +1 more source

Nonlocal Optimal Control in the Source—Numerical Approximation of the Compliance Functional Constrained by the p-Laplacian Equation

open access: yesMathematics
The goal of this manuscript is the study of an optimal control problem. It consists on the minimization of the compliance functional when the state equation is the nonlocal p-laplacian and the control is the source of this equation.
Damián Castaño, Julio Muñoz
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Optimal Flood Control [PDF]

open access: yes, 2011
A mathematical model for optimal control of the water levels in a chain of reservoirs is studied. Some remarks regarding sensitivity with respect to the time horizon, terminal cost and forecast of inflow are ...
Hulshof, J, Ran, A, Dickinson, P
core  

A hybrid multi-stage optimization approach for multi-vehicle motion planning problems with lane changing

open access: yesComplex & Intelligent Systems
The multi-vehicle motion planning for lane change scenario is one of the frontiers and hotspots of intelligent transportation research. It is usually modeled as a complex and constrained optimal control problem, especially when there are obstacles on the
Long Xiao   +3 more
doaj   +1 more source

Kinematically Optimal Robust Control of Redundant Manipulators

open access: yesInternational Journal of Applied Mechanics and Engineering, 2017
This work deals with the problem of the robust optimal task space trajectory tracking subject to finite-time convergence. Kinematic and dynamic equations of a redundant manipulator are assumed to be uncertain.
M. Galicki
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Optimal fluctuations and the control of chaos. [PDF]

open access: yes, 2002
The energy-optimal migration of a chaotic oscillator from one attractor to another coexisting attractor is investigated via an analogy between the Hamiltonian theory of fluctuations and Hamiltonian formulation of the control problem.
Luchinsky, D. G.   +4 more
core  

Optimal Modal Control

open access: yesMeasurement + Control, 1973
In this paper, optimal and modal control theories are combined to form a new theory of optimal modal control. This theory provides a rational basis for the selection of a modal state weighting matrix which ensures that the plant matrix of the resulting ...
M. A. Woodhead, B. Porter
doaj   +1 more source

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