Results 91 to 100 of about 1,404,150 (268)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Structure Analysis and Heat Transfer Performance Study on Spiral Plate of the Adsorption Bed

Zhileng xuebao, 2013
The advantages and disadvantages of the spiral plate adsorption bed are analyzed. The heat transfer process and the demand of cold and heat sources in a spiral plate adsorption bed, which is designed with counter-flow heat transfer and based on 15kW ...
Chen Huanxin, Wei Li, Zhang Wei, Dong Yuanyuan, Zhu Jing, Zhang Chuo, Yin Ming   +6 more
doaj  

Development and Characteristic Test of Downhole Alternating Flow Field ROP Enhancing Tool

Shiyou jixie, 2020
Existing pulse jet tools have the problems of large pulse intensity loss and inferior ROP enhancement performance. To address the problem, a new type of downhole alternating flow field ROP enhancing tool is developed.
Fan Jiqiang
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Multi-Objective PFC Boost Inductor Optimal Design Algorithm Based on Pareto Front

Energies
In this study, the inductor optimization design is performed by applying the Pareto optimization technique. As environmental problems emerge, the electric vehicle market is expanding, and accordingly, volume reduction and high efficiency of the onboard ...
Ye-Ji Hyeon, Dong-In Lee, Seong-Wook Jeong, Han-Shin Youn   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Adaptive Exploration Artificial Bee Colony for Mathematical Optimization

AI
The artificial bee colony (ABC) algorithm is a famous swarm intelligence method utilized across various disciplines due to its robustness. However, it exhibits limitations in exploration mechanisms, particularly in high-dimensional or complex landscapes.
Shaymaa Alsamia, Edina Koch, Hazim Albedran, Richard Ray   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Coupled Design and Operation Optimization for Decarbonization of Industrial Energy Systems Using an Open-Source In-House Tool

Eng
The decarbonization of industrial energy systems which comprise different networks (such as steam, water, electric power, fuel sources) is crucial for mitigating climate change and achieving sustainability goals.
Rushit Kansara, María Isabel Roldán Serrano   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source