Results 131 to 140 of about 12,714,502 (313)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Coupled Design and Operation Optimization for Decarbonization of Industrial Energy Systems Using an Open-Source In-House Tool

Eng
The decarbonization of industrial energy systems which comprise different networks (such as steam, water, electric power, fuel sources) is crucial for mitigating climate change and achieving sustainability goals.
Rushit Kansara, María Isabel Roldán Serrano   +1 more
doaj   +1 more source

Nonparametric time trends in optimal design of experiments. [PDF]

When performing an experiment, the observed responses are often influenced by a temporal trend due to aging of material, learning effects, equipment wear-out, warm-up effects, etc. The construction of run orders that are optimally balanced for time trend
Tack, Lieven, Vandebroek, Martina
core  

Applications Oriented Optimal Input Design for MPC: An analysis of a quadruple water tank process [PDF]

, 2013
Model predictive control (MPC) makes use of a model of the system, therefore performances are highly dependent on the accuracy of the model chosen. Applications oriented optimal input design enables optimization of the system identification experiments ...
Balsemin, Antonio
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multi-Physics Based Optimal Design of an Axial-Flux Ferrite Consequent-Pole Motor for Permanent Magnet Reduction Using 3D Finite Element Analysis

Applied Sciences
This paper proposes a multiphysics-based optimal design process for a 750 W axial-flux ferrite consequent-pole (AFCP) pump motor aimed at reducing permanent magnet usage.
Hyeon-Jun Kim, Soo-Whang Baek
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Optimal Design of a Coaxial Magnetic Gear Considering Thermal Demagnetization and Structural Robustness for Torque Density Enhancement

Actuators
This study presents an optimal design combined with comprehensive multiphysics validation to enhance the torque density of a coaxial magnetic gear (CMG) incorporating an overhang structure.
Tae-Kyu Ji, Soo-Whang Baek
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Study on Optimization Methods for Miniaturization and Lightweight Design of Micro Lead-bismuth Cooled Reactor

Yuanzineng kexue jishu
Lead-bismuth cooled reactors utilizing liquid lead-bismuth as a coolant in the primary loop system are an advanced nuclear energy system with significant developmental prospects.
LIU Zijing, ZHAO Pengcheng, LI Qiong
doaj   +1 more source