Results 121 to 130 of about 12,714,502 (313)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Structure Analysis and Heat Transfer Performance Study on Spiral Plate of the Adsorption Bed
Zhileng xuebao, 2013 The advantages and disadvantages of the spiral plate adsorption bed are analyzed. The heat transfer process and the demand of cold and heat sources in a spiral plate adsorption bed, which is designed with counter-flow heat transfer and based on 15kW ...
Chen Huanxin +6 more
doaj
Development and Characteristic Test of Downhole Alternating Flow Field ROP Enhancing Tool
Shiyou jixie, 2020 Existing pulse jet tools have the problems of large pulse intensity loss and inferior ROP enhancement performance. To address the problem, a new type of downhole alternating flow field ROP enhancing tool is developed.
Fan Jiqiang
doaj
Bayesian sequential D-D optimal model-robust designs. [PDF]
Alphabetic optimal design theory assumes that the model for which the optimal design is derived is usually known. However in real-life applications, this assumption may not be credible, as models are rarely known in advance.
Ruggoo, A, Vandebroek, Martina
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Multi-Objective PFC Boost Inductor Optimal Design Algorithm Based on Pareto Front
EnergiesIn this study, the inductor optimization design is performed by applying the Pareto optimization technique. As environmental problems emerge, the electric vehicle market is expanding, and accordingly, volume reduction and high efficiency of the onboard ...
Ye-Ji Hyeon +3 more
doaj +1 more source
A geometric characterization of c-optimal designs for heteroscedastic regression [PDF]
We consider the common nonlinear regression model where the variance as well as the mean is a parametric function of the explanatory variables. The c-optimal design problem is investigated in the case when the parameters of both the mean and the variance
Dette, Holger, Holland-Letz, Tim
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Adaptive Exploration Artificial Bee Colony for Mathematical Optimization
AIThe artificial bee colony (ABC) algorithm is a famous swarm intelligence method utilized across various disciplines due to its robustness. However, it exhibits limitations in exploration mechanisms, particularly in high-dimensional or complex landscapes.
Shaymaa Alsamia +3 more
doaj +1 more source