Results 91 to 100 of about 323,365 (265)

Open Drainage and Detention Basin Combined System Optimization

مجله آب و خاک, 2017
Introduction: Since flooding causes death and economic damages, then it is important and is one of the most complex and destructive natural disaster that endangers human lives and properties compared to any other natural disasters.
M. E. Banihabib, S. Mirmomen, M. Eivazi
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multi-objective ergonomics design model optimization for micro electric cars via response surface methodology

Discover Applied Sciences
Despite advancements in ergonomic comfort assessments in automotive design, optimizing seat dimensions within the constrained spaces of micro-electric cars presents a substantial challenge.
Ayman R. Mohammed, Zead Saleh, Alhassan M. Aldabbagh, Ahmad Al Hanbali   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

On Steiner Trees of the regular simplex

Journal of Computational Geometry
In the Euclidean Steiner Tree problem, we are given as input a set of points (called terminals) in the $\ell_2$-metric space and the goal is to find the minimum-cost tree connecting them.
Henry Fleischmann, Guillermo Gamboa Quintero, Karthik C. S., Josef Matějka, Jakub Petr   +4 more
doaj   +1 more source

Machine Learning-Based Dimension Optimization for Two-Stage Precoder in Massive MIMO Systems with Limited Feedback

Applied Sciences, 2019
A two-stage precoder is widely considered in frequency division duplex massive multiple-input and multiple-output (MIMO) systems to resolve the channel feedback overhead problem.
Jinho Kang, Jung Hoon Lee, Wan Choi
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Enhancing LS-PIE’s Optimal Latent Dimensional Identification: Latent Expansion and Latent Condensation

Mathematical and Computational Applications
The Latent Space Perspicacity and Interpretation Enhancement (LS-PIE) framework enhances dimensionality reduction methods for linear latent variable models (LVMs).
Jesse Stevens, Daniel N. Wilke, Isaac I. Setshedi   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source