Results 91 to 100 of about 60,783 (290)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Parallel 3D Bioprinting on SLIPS‐Microarrays

Advanced Functional Materials, EarlyView.
This work introduces the first truly parallel 3D bioprinting method, enabling both the simultaneous fabrication of hundreds of cell laden hydrogel 3D structures and their HTS in individual liquid compartments. By integrating Digital Light Processing (DLP) stereolithography with functional micropatterns, the platform decouples printing time from array ...
Julius von Padberg, Julian A. Serna, Maike Schliephake, Pavel A. Levkin   +3 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

KO algorithm-based bi-level optimal scheduling of electricity-carbon-hydrogen coupling systems with flexible resources for renewable energy integration

Results in Engineering
As renewable energy penetration keeps growing, its intermittent nature poses huge challenges on the reliable and flexible operation of power systems. The uncertainty and reverse peak shaving characteristics of renewable energy further exacerbate issues ...
Jing Liu, Zicheng Guo, Yalong Li
doaj   +1 more source

Compressed Air Energy Storage-Part II: Application to Power System Unit Commitment

, 2017
Unit commitment (UC) is one of the most important power system operation problems. To integrate higher penetration of wind power into power systems, more compressed air energy storage (CAES) plants are being built.
Ansari, Osama Aslam, Chung, C. Y., Wen, Yunfeng, Zhan, Junpeng   +3 more
core  

Photon Avalanching Nanoparticles: The Next Generation of Upconverting Nanomaterials?

Advanced Functional Materials, EarlyView.
This Perspective outlines the mechanistic foundations that enable photon‐avalanche (PA) behavior in lanthanide nanomaterials and contrasts them with emerging application spaces and forward‐looking design strategies. By bridging threshold engineering, energy‐transfer dynamics, and materials engineering, we provide a coherent roadmap for advancing the ...
Kimoon Lee, Yunseo Kim, Hyeong‐ku Jo, Dongjoon Yoon, Byeonghyeok Im, WonJeong Yu, Eui‐Rim On, Changhwan Lee   +7 more
wiley   +1 more source

Ac-Aware Optimization Framework for Under-Frequency Load Shedding

Under-frequency load shedding (UFLS) prevents system collapse during large disturbances. Increased penetration of distributed energy resources (DERs) and reduced system inertia makes it challenging to design a static UFLS scheme, which relies on preset frequency thresholds and load shed fractions to meet design criteria across all possible operating ...
Elsaadany, Mazen, Ali, Muhammad Hamza, Pandey, Amritanshu, Almassalkhi, Mads R.   +3 more
openaire   +2 more sources

Engineering Strategies for Stable and Long‐Life Alkaline Zinc‐Based Flow Batteries

Advanced Functional Materials, EarlyView.
Alkaline zinc‐based flow batteries face persistent challenges from unstable zinc deposition, including dendrite growth, passivation, corrosion, and hydrogen evolution, which severely limit cycling stability. Current research addresses these issues through coordinated electrode structuring, electrolyte regulation, and membrane design to control zinc ...
Yuran Bai, Xiaoyu Huo, Xin Long, Enkang Fu, Xusong Gong, Lei Wei, Liang An   +6 more
wiley   +1 more source

Mitigation Impact of Critical Contingencies in Electric Power Grid using PSO-Based Maximum Constrained Load-Shedding Technique

Journal of Engineering
This study presents a Particle Swarm Optimization (PSO)-based scheme for optimal targeted load shedding and contingency severity assessment in the electric power grid (EPG). The IEEE 14 EPG was used as a testbed.
Sunday Adetona, Odunayo Odusanya, Adeola Balogun, Frank Okafor   +3 more
doaj   +1 more source

Robust Polymer Hydrogels Improve Electric‐Fish‐Inspired Batteries

Advanced Functional Materials, EarlyView.
ABSTRACT Electric‐fish‐inspired hydrogel batteries based on ion‐concentration gradients offer an attractive route to soft power sources; however, the poor mechanical properties of existing hydrogels limit device assembly and performance. Here, we report poly(ethylene glycol) methyl ether acrylate hydrogels that enable ion‐gradient batteries composed of
Nick Zahnd, Satyajit Das, John Marc C. Puguan, Carolina Pierucci, Michael Mayer, Christoph Weder   +5 more
wiley   +1 more source