Results 111 to 120 of about 2,082,796 (308)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A novel methodology for optimal location of reactive compensation through deep neural networks. [PDF]

Heliyon, 2022
Jaramillo M, Tipán L, Muñoz J.
europepmc   +1 more source

Location-Based Beamforming and Physical Layer Security in Rician Wiretap Channels

, 2016
We propose a new location-based beamforming (LBB) scheme for wiretap channels, where a multi-antenna source communicates with a single-antenna legitimate receiver in the presence of a multi-antenna eavesdropper.
Liu, Chenxi, Malaney, Robert
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimal Placement of Pressure Gauges for Water Distribution Networks Using Entropy Theory Based on Pressure Dependent Hydraulic Simulation

Entropy, 2018
This study proposed a pressure driven entropy method (PDEM) that determines a priority order of pressure gauge locations, which enables the impact of abnormal condition (e.g., pipe failures) to be quantitatively identified in water distribution networks (
Do Guen Yoo, Dong Eil Chang, Yang Ho Song, Jung Ho Lee   +3 more
doaj   +1 more source

Subthalamic deep brain stimulation for primary dystonia: defining an optimal location using the medial subthalamic nucleus border as anatomical reference. [PDF]

Front Aging Neurosci, 2023
Zhao M, Chen H, Yan X, Li J, Lu C, Cui B, Huo W, Cao S, Guo H, Liu S, Yang C, Liu Y, Yin F.   +12 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

THE STUDY FOR SUBSTANTIATE OPTIMAL LOCATION FOR A PROCESSING RAPESEED FACTORY IN CALARASI COUNTY [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014
To ensure a high economic efficiency of productive work is necessary to determine the optimal location of the objective investment. Optimal location creates a prerequisite for approaching the maximum level of investment efficiency both in the national ...
Ioana NICULAE, Georgiana Melania COSTAICHE, Alina MARCUŢĂ, Liviu MĂRCUŢĂ, Aurelia BALAN   +4 more
doaj  

Optimal Location of Navy Recruiters

, 2018
Salmeron, Javier , Buttrey: Principal Investigator NPS-17-N326-A Navy - N1 - Manpower, Personnel, Training ...
Salmeron, Javier, Buttrey, Samuel E.
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source