Results 121 to 130 of about 3,904,834 (301)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Optimal scheduling of maintenance dredging in a maritime transportation system
Maritime Transport ResearchA maritime transportation system is a network of ports and commercial terminals connected by navigation channels and navigable inland rivers that enables international trade and the global supply chain.
Michael Hanowsky +4 more
doaj +1 more source
A prospective observational study on the optimal maintenance strategy in HER2-positive advanced gastric cancer treated with trastuzumab-based therapy. [PDF]
J Cancer Res Clin Oncol, 2020 Li Q +7 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
prepared by the Maintenance Division of the Oregon State Highway Department."March, 1964."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not
core
The development of a hybrid intelligent maintenance optimisation system (HIMOS).
, 2001 This paper reports on the development of a hybrid intelligent maintenance optimisation system (HIMOS) for decision support. It is a follow-up to an earlier paper published in the Journal of the Operational Research Society in 1995.
Jeon, J, Kobbacy, KAH
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
An optimal integrated maintenance for multi parallel workstations under returned products
, 2015 International audienceThis paper treaties an integrated maintenance problem of manufacturing system with considering a returned products and leasing constraints.
Hajej, Zied +5 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source