Results 101 to 110 of about 3,904,834 (301)

An optimal production/maintenance strategy under lease contract with warranty periods

, 2016
International audiencePurpose – The purpose of this paper is to investigate the optimal production policy and maintenance strategy for leased equipment under a lease contract with warranty periods.
Hajej, Zied, Gharbi, Ali, Rezg, Nidhal
core   +1 more source

Effectiveness, safety, initial optimal dose, and optimal maintenance dose range of basal insulin regimens for type 2 diabetes: A systematic review with meta-analysis. [PDF]

J Diabetes, 2023
Luo Y, Xia J, Zhao Z, Chang Y, Bee YM, Nguyen KT, Lim S, Yabe D, McGill M, Kong APS, Chan SP, Deodat M, Deerochanawong C, Suastika K, Xu C, Chen L, Chen W, Li X, Zhao W, Yao X, Ji L.   +20 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Structural Properties of Optimal Maintenance Policies for k-out-of-n Systems with Interdependence Between Internal Deterioration and External Shocks

Mathematics
Many modern engineering systems, such as offshore wind turbines, rely on k-out-of-n configurations to ensure reliability. These systems are exposed to both internal deterioration and external shocks, which can significantly impact operational efficiency ...
Mizuki Kasuya, Lu Jin
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Markov model for opportunity maintenance [PDF]

Maintenance;produktieleer ...
Vanneste, S.G.
core  

Reliability analysis-based life cycle assessment of railway components using long-term maintenance data

Developments in the Built Environment
This study proposes a framework to evaluate the reliability of rail operation times and optimal maintenance intervals for sleepers and fasteners using a long-term maintenance database in South Korea.
Koochul Ji, Ilyoon Choi, Jongmuk Won
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Modelling and Optimizing Imperfect Maintenance of Coatings on Steel Structures [PDF]

Steel structures such as bridges, tanks and pylons are exposed to outdoor weathering conditions. In order to prevent them from corrosion they are protected by an organic coating system.
Dekker, R., Nicolai, R.P., Frenk, J.B.G.
core  

Clinical option of pemetrexed-based versus paclitaxel-based first-line chemotherapeutic regimens in combination with bevacizumab for advanced non-squamous non-small-cell lung cancer and optimal maintenance therapy: evidence from a meta-analysis of randomized control trials. [PDF]

BMC Cancer, 2021
Huang LT, Cao R, Wang YR, Sun L, Zhang XY, Guo YJ, Zhao JZ, Zhang SL, Jing W, Song J, Han CB, Ma J.   +11 more
europepmc   +1 more source