Results 81 to 90 of about 3,904,834 (301)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2011 International audienceThis paper deals with combined production and maintenance plans for a manufacturing system satisfying a random demand. We first establish an optimal production plan which minimizes the average total inventory and production cost ...
Dellagi, Sofiene +2 more
core +1 more source
Cost-Optimal Maintenance Planning for Defects on Wind Turbine Blades
Energies, 2019 Due to the considerable increase in clean energy demand, there is a significant trend of increased wind turbine sizes, resulting in much higher loads on the blades.
Yi Yang, John Dalsgaard Sørensen
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Optimal Maintenance Policy for a Markov Deteriorating System Under Reliability Limit
In this study, failure data of computer numerical control machine used in defense industry was analyzed to develop maintenance algorithm with a Markov feature. An imperfect preventive maintenance model that minimizes long-term operational cost is created
Khaniyev, Tahir, Ozturk, Meltem Kocer
core +1 more source
Reviews and case studies: Research opportunities in maintenance of office building services systems [PDF]
, 2010 Purpose - The purpose of this study is to highlight special characteristics of building services systems and investigate how practitioners view reliability and maintenance.
Hornby, Matthew +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2021 One way to reduce maintenance cost and maximize system safety and reliability is to implement the most appropriate maintenance strategy for the system. There are different maintenance strategies and the task of choosing the optimal strategy is cumbersome
Oreko, B.U., Emovon, I.
core +1 more source