Results 71 to 80 of about 3,904,834 (301)
Optimal preventive-maintenance warranty policy for repairable products
, 2011 This paper investigates preventive-maintenance warranty (PMW) policies for repairable products. When the length of a warranty period is pre-specified, the optimal number of preventive maintenance actions, corresponding maintenance degrees, and the ...
Yeh, Ruey-huei ; 羅惠瓊; Lo, Hui-chiung
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
EngineeringWind farm operators always need a better maintenance strategy to increase resource utilization efficiency while controlling operation and maintenance costs.
Dongming Fan +7 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Optimal maintenance of multi-component systems: a review [PDF]
In this article we give an overview of the literature on multi-component maintenance optimization. We focus on work appearing since the 1991 survey "A survey of maintenance models for multi-unit systems" by Cho and Parlar.
Dekker, R., Nicolai, R.P.
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
OPTIMAL RAILWAY INFRASTRUCTURE MAINTENANCE AND REPAIR POLICIES TO MANAGE RISK UNDER UNCERTAINTY WITH ADAPTIVE CONTROL [PDF]
The aim of this paper is to apply two adaptive control formulations under uncertainty, say open-loop and closed-loop, to the process of developing maintenance and repair policies for railway infrastructures.
Jesus Carretero +3 more
core
Optimal maintenance management for synchronous generators: A condition-based approach to predict and assess equipment wear [PDF]
E3S Web of ConferencesCurrently, effective and early detection of potential failures is of paramount importance in power generation systems, posing a significant challenge for generating companies.
Vargas Geovanny Jimenez +1 more
doaj +1 more source