Results 91 to 100 of about 674,988 (292)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Structural health monitoring and bridge condition assessment [PDF]

open access: yes, 2016
Thesis (Ph.D.) University of Alaska Fairbanks, 2016This research is mainly in the field of structural identification and model calibration, optimal sensor placement, and structural health monitoring application for large-scale structures.
Xiao, Feng, 肖枫
core  

On Caching with More Users than Files

open access: yes, 2016
Caching appears to be an efficient way to reduce peak hour network traffic congestion by storing some content at the user's cache without knowledge of later demands.
Piantanida, Pablo   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

3D Placement of an Unmanned Aerial Vehicle Base Station (UAV-BS) for Energy-Efficient Maximal Coverage

open access: yes, 2017
Unmanned Aerial Vehicle mounted base stations (UAV-BSs) can provide wireless services in a variety of scenarios. In this letter, we propose an optimal placement algorithm for UAV-BSs that maximizes the number of covered users using the minimum transmit ...
Alzenad, Mohamed   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Optimal Sensors Placement to Enhance Damage Detection in Composite Plates [PDF]

open access: yes, 2014
This paper examines an important challenge in ultrasonic structural health monitoring (SHM), which is the problem of the optimal placement of sensors in order to accurately detect and localize damages.
COFFIGNAL, Gérard   +5 more
core   +3 more sources

3D Placement Optimization in UAV-Enabled Communications: A Systematic Mapping Study

open access: yesIEEE Open Journal of Vehicular Technology
Unmanned aerial vehicles (UAVs) have seen remarkable improvements in their flight capabilities and computational power. Their applications span various domains, such as agriculture, military, and communications.
Jorge Carvajal-Rodriguez   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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