Results 51 to 60 of about 277,821 (256)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimal Power Flow in Direct-Current Power Grids via Black Hole Optimization

Advances in Electrical and Electronic Engineering, 2019
This paper addresses the Optimal Power Flow (OPF) problem in DC power microgrids via a combinatorial optimization technique known as Black Hole Optimization (BHO).
Orfilio Sebastian Velasquez, Oscar Danilo Montoya Giraldo, Victor Manuel Garrido Arevalo, Luis Fernando Grisales Norena   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advances in Transient Stability-Constrained Optimal Power Flow of Power Systems

CSEE Journal of Power and Energy Systems
Transient stability-constrained optimal power flow (TSCOPF) optimizes power flow while ensuring stability against potential contingencies. The main challenges faced by TSCOPF are the handling of transient constraints.
Hang Zhang, Yan Xu, Zhao Yang Dong
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Distributed Optimal Power Flow for Large-Scale Multi-Area Interconnected Power Systems

CSEE Journal of Power and Energy Systems
Distributed optimal power flow (OPF) of large-scale multi-area interconnected power systems is a challenging problem. This letter proposes a distributed OPF approach based on the modified decomposition-coordination interior point method (DCIPM).
Qingju Luo, Jizhong Zhu, Haohao Zhu, Di Zhang   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Contingency-Constrained Optimal Power Flow Using Simplex-Based Chaotic-PSO Algorithm

Applied Computational Intelligence and Soft Computing, 2011
This paper proposes solving contingency-constrained optimal power flow (CC-OPF) by a simplex-based chaotic particle swarm optimization (SCPSO). The associated objective of CC-OPF with the considered valve-point loading effects of generators is to ...
Zwe-Lee Gaing, Chia-Hung Lin
doaj   +1 more source

Remedial transactions curtailment via optimization [PDF]

Serbian Journal of Electrical Engineering, 2009
The new method developed in this paper is aiming at transmission congestion management (CM). The new, Optimal Transactions Management method (OTM), is based on linear programming (LP), DC load flow (DCLF) and linear security constraints.
Maksimović Viktor, Škokljev Ivan
doaj   +1 more source

Online optimal power flow with renewables [PDF]

2014 48th Asilomar Conference on Signals, Systems and Computers, 2014
Optimal power flow (OPF) is a critical control task for reliable and efficient operation of power grids. Significant challenges are anticipated in the development of future power systems, as a substantial amount of inherently uncertain renewable resources are incorporated, imposing volatile dynamics to the grid.
Seung-Jun Kim 0002, Georgios B. Giannakis, Kwang Y. Lee   +2 more
openaire   +1 more source