Results 91 to 100 of about 2,748,769 (296)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An optimal procedure for the unconstrained max-NPV project scheduling problem with generalized precedence relations. [PDF]

The unconstrained max-npv project scheduling problem involves the scheduling of the activities of a project in order to maximize its net present value. Assume a project represented in activity-on-mode (AoN) notation, in which the activities have a known ...
De Reyck, B, Herroelen, Willy
core  

Optimal scheduling of the stand‐alone micro grids considering the reliability cost

The Journal of Engineering
In order to prevent wastage of generated power of renewable resources, the energy storage systems can be utilized in the stand‐alone micro grids to store the excess produced power of the renewable generation units.
Ayoub Nargeszar, Amir Ghaedi, Mehdi Nafar, Mohsen Simab   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An optimal-control based integrated model of supply chain [PDF]

Problems of supply chain scheduling are challenged by high complexity, combination of continuous and discrete processes, integrated production and transportation operations as well as dynamics and resulting requirements for adaptability and stability ...
Ivanov, Dmitry
core  

Lot streaming and batch scheduling: splitting and grouping jobs to improve production efficiency

, 2001
This thesis deals with issues arising in manufacturing, in particular related to production efficiency. Lot streaming refers to the process of splitting jobs to move production through several stages as quickly as possible, whereas batch scheduling ...
Possani, Edgar
core   +1 more source

Source-network-load-storage collaborated two-stage power dispatch of active distribution network with conditional value-at-risk

International Journal of Electrical Power & Energy Systems
The high penetration of distributed wind turbines (WT) and photovoltaics (PV) brings temporal volatility and uncertainty to their output, posing significant challenges to the optimal scheduling of distribution networks.
Shiwei Xia, Yifeng Wang, Xinyuan Hu, Yuting Yan, Mingze Tong, Haowen Liang, Xiaoyun Wu, Jian Huo   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Fifty years of scheduling: a survey of milestones [PDF]

, 2009
Scheduling has become a major field within operational research with several hundred publications appearing each year. This paper explores the historical development of the subject since the mid 1950s when the landmark publications started to appear.
Strusevich, Vitaly A., Strusevich, V.A., Potts, Christopher N., Potts, C.N., C N Potts, V A Strusevich   +5 more
core   +1 more source

Adaptive genetic algorithm for computer course scheduling system under the background of educational informatization

Systems and Soft Computing
Currently, traditional scheduling methods are difficult to cope with the increasing demand and complexity of education, especially when dealing with large-scale data, diverse course schedules, and personalized teaching needs.
Lingzhi Yan, Hua Deng
doaj   +1 more source