Results 81 to 90 of about 375,660 (286)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Application of hyperbolic partial differential equations in global optimal scheduling of UAV

open access: yesAlexandria Engineering Journal, 2020
The global optimal scheduling of UAV (unmanned aerial vehicle) navigation channel is studied. Firstly, a multi-channel optimal scheduling mathematical model based on the HPDEs (hyperbolic partial differential equations) wave combination optimization is ...
Chong Tian, Kuo-Chi Chang, JinSong Chen
doaj   +1 more source

On Optimal Weighted-Delay Scheduling in Input-Queued Switches

open access: yes, 2017
Motivated by relatively few delay-optimal scheduling results, in comparison to results on throughput optimality, we investigate an input-queued switch scheduling problem in which the objective is to minimize a linear function of the queue-length vector ...
Lu, Yingdong   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimal Sizing of Energy Storage in Photovoltaic-Energy Storage DC Distribution Network Considering Uncertainty

open access: yes南方能源建设
[Objective] In order to balance the relationship between multiple objectives in the photovoltaic-energy storage DC distribution network and realize the optimal scheduling of energy storage capacity, an optimal scheduling method for energy storage ...
Junyang XIAO   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Optimal strategies of radial velocity observations in planet search surveys

open access: yes, 2008
Applications of the theory of optimal design of experiments to radial velocity planet search surveys are considered. Different optimality criteria are discussed, basing on the Fisher, Shannon, and Kullback-Leibler informations.
Baluev   +22 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Fuzzy Byproduct Gas Scheduling in the Steel Plant Considering Uncertainty and Risk Analysis

open access: yesEnergies, 2018
In the iron and steel enterprises, efficient utilization of byproduct gas is of great significance for energy conservation and emission reduction. This work presents a fuzzy optimal scheduling model for byproduct gas system.
Xueying Sun, Zhuo Wang, Jingtao Hu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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