Results 41 to 50 of about 4,146,021 (290)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

STABILITIY OF THE SYNTAGMATIC PROBABILITY DISTRIBUTIONS [PDF]

open access: yesPsihologija, 2009
The aim of the present study is to establish criteria for the optimal sizeof a corpus that can provide stable conditional probabilities of morphologicaland/or syntagmatic types. The optimality of corpus size is defined in terms ofthe smallest sample that
Strahinja Dimitrijevic   +2 more
doaj  

Optimization of the Size of Nonsensitiveness Regions [PDF]

open access: yesApplications of Mathematics, 2002
The standard statistical procedures based on a linear regression model are influenced by the inaccuracy \(\delta \mathbf \vartheta \) in the value of variance components. In the paper, its effect is considered on the risk of a standard test. Let the risk \(\alpha \) be worse by \(\epsilon \), i.e., let the level of the test be \(\alpha +\epsilon ...
openaire   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Committee Size and Smart Growth: An Optimal Solution [PDF]

open access: yes, 2009
Wisconsin is one of many states that have enacted a “Smart Growth Initiative” law that requires inclusion of the public in the creation and development of a Comprehensive Plan.
Kashian, Russell, Kohls, Heather
core   +1 more source

Optimal Sample Size Planning for the Wilcoxon-Mann-Whitney-Test

open access: yes, 2018
There are many different proposed procedures for sample size planning for the Wilcoxon-Mann-Whitney test at given type-I and type-II error rates $\alpha$ and $\beta$, respectively.
Akritas   +29 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Steady State Economy at Optimal Population Size

open access: yesThe Journal of Population and Sustainability, 2018
This paper reviews briefly the idea of a steady state economy from the ancient times to the present. It discusses some of the suggestions made by H. Daly in his model of a steady state economy and particularly the idea of a stable population. It suggests
Theodore Lianos
doaj   +1 more source

Formalizing Size-Optimal Sorting Networks: Extracting a Certified Proof Checker

open access: yes, 2015
Since the proof of the four color theorem in 1976, computer-generated proofs have become a reality in mathematics and computer science. During the last decade, we have seen formal proofs using verified proof assistants being used to verify the validity ...
A Fouilhe   +11 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

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