Results 71 to 80 of about 78,187 (304)
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Constructing time-homogeneous generalized diffusions consistent with optimal stopping values [PDF]
, 2010 Consider a set of discounted optimal stopping problems for a one-parameter family of objective functions and a fixed diffusion process, started at a fixed point.
Hobson, David (David G.) +5 more
core +1 more source
Optimal Investment under Cost Uncertainty
Risks, 2018 This paper studies the valuation of real options when the cost of investment jumps at a random time. Three valuation formulas are derived. The first expresses the value of the project in terms of a collection of knockout barrier claims.
Jerome Detemple, Yerkin Kitapbayev
doaj +1 more source
Discounted Optimal Stopping of a Brownian Bridge, with Application to American Options under Pinning
Mathematics, 2020 Mathematically, the execution of an American-style financial derivative is commonly reduced to solving an optimal stopping problem. Breaking the general assumption that the knowledge of the holder is restricted to the price history of the underlying ...
Bernardo D’Auria +2 more
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Randomized Stopping Points and Optimal Stopping on the Plane
The Annals of Probability, 1992 The notion of randomized stopping points (for one-parameter processes (1- rsp's)), introduced by Baxter and Chacon, is here extended in a suitable way to 2-rsp's. This extension, linked with a theorem of Baxter and Chacon, serves to identify a correspondence between adapted random measures on \(\mathbb{N}^ 2\) and 2-rsp's.
openaire +3 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Journal of Applied Mathematics, 2015 The target of this paper is to establish the bid-ask pricing framework for the American contingent claims against risky assets with G-asset price systems on the financial market under Knightian uncertainty. First, we prove G-Dooby-Meyer decomposition for
Wei Chen
doaj +1 more source
Secretary Problem with Possible Errors in Observation
Mathematics, 2020 The classical secretary problem models a situation in which the decision maker can select or reject in the sequential observation objects numbered by the relative ranks.
Marek Skarupski
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source