Results 61 to 70 of about 173,418 (245)
Health Technology AssessmentBackground Bariatric surgery is a common procedure worldwide for the treatment of severe obesity and associated comorbid conditions but there is a lack of evidence as to medium-term safety and effectiveness outcomes in a United Kingdom setting. Objective
Ruth M Mackenzie +12 more
doaj +1 more source
Optimal design of multi‐arm multi‐stage trials
Statistics in Medicine, 2012 In drug development, there is often uncertainty about the most promising among a set of different treatments. Multi‐arm multi‐stage (MAMS) trials provide large gains in efficiency over separate randomised trials of each treatment.
J. Wason, T. Jaki
semanticscholar +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
Predicting the ultimate supremum of a stable L\'{e}vy process with no negative jumps
, 2012 Given a stable L\'{e}vy process $X=(X_t)_{0\le t\le T}$ of index $\alpha\in(1,2)$ with no negative jumps, and letting $S_t=\sup_{0\le s\le t}X_s$ denote its running supremum for $t\in [0,T]$, we consider the optimal prediction problem \[V=\inf_{0\le\tau ...
Bernyk, Violetta +2 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti +19 more
wiley +1 more source
A Conversation with Yuan Shih Chow
, 2006 Yuan Shih Chow was born in Hubei province in China, on September 1, 1924. The eldest child of a local militia and political leader, he grew up in war and turmoil.
Ying, Zhiliang, Zhang, Cun-Hui
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Associations of Sleep and Shift Work With Osteoarthritis Risk
Arthritis Care &Research, EarlyView.Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik +5 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Objectives This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah +6 more
wiley +1 more source
Asymptotic operating characteristics of an optimal change point detection in hidden Markov models
, 2005 Let \xi_0,\xi_1,...,\xi_{\omega-1} be observations from the hidden Markov model with probability distribution P^{\theta_0}, and let \xi_{\omega},\xi_{\omega+1},...
Fuh, Cheng-Der
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Advanced Engineering Materials, EarlyView.The formation of nonmetallic inclusions (NMIs) was investigated in this study, carrying out immersion tests for 30 min at a temperature of 1600°C with liquid high‐silicon electrical steel (Si ≈ 3 mass‐%) and different MgO–C refractories. Conventional MgO–C refractories were considered, as well as MgO–C refractories containing MgO–C recyclate and ...
Lukas Neubert +6 more
wiley +1 more source