Results 31 to 40 of about 5,276,757 (246)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Lie group analysis, solitons, self-adjointness and conservation laws of the nonlinear elastic structural element equation

open access: yesJournal of Taibah University for Science
This study is based on the Lie group method for the nonlinear elastic structural element equation (ESE Equation). We obtain a three-dimensional Lie algebra. By utilizing this Lie algebra a four-dimensional optimal system is constructed. The governing ESE
Akhtar Hussain   +2 more
doaj   +1 more source

In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies

open access: yesNanomaterials, 2018
Triamcinolone acetonide (TA), an intermediate acting corticosteroid, is used in the treatment of posterior ocular diseases, such as inflammation, posterior uveitis, and diabetic macular edema.
Akshaya Tatke   +6 more
doaj   +1 more source

Penrose voting system and optimal quota [PDF]

open access: yes, 2006
Systems of indirect voting based on the principle of qualified majority can be analysed using the methods of game theory. In particular, this applies to the voting system in the Council of the European Union, which was recently a subject of a vivid ...
Slomczynski, Wojciech, Zyczkowski, Karol
core   +1 more source

Stochastic Analysis of Power-Aware Scheduling [PDF]

open access: yes, 2008
Energy consumption in a computer system can be reduced by dynamic speed scaling, which adapts the processing speed to the current load. This paper studies the optimal way to adjust speed to balance mean response time and mean energy consumption, when ...
Andrew, Lachlan L. H.   +2 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Optimal Energy System for Repowering Yemen’s Cities

open access: yesChemical Engineering Transactions, 2022
As a result of the ongoing conflict in Yemen, the country’s energy infrastructure and supply deficiency has worsened dramatically from its pre-existing poor levels, creating significant consequences for the population's essential needs.
Mohammed Abdulrahman Saleh Almurisi   +1 more
doaj   +1 more source

Optimal electric-drive system for vehicles [PDF]

open access: yes, 1970
Pulse-width-modulated controller, for vehicle electrically driven by direct current from storage battery and requiring highest possible efficiency in battery use, varies electrical power through silicon controlled rectifiers for permanent magnet dc ...
Sahinkaya, Y. E.
core   +1 more source

Optimal motion control and vibration suppression of flexible systems with inaccessible outputs [PDF]

open access: yes, 2011
This work addresses the optimal control problem of dynamical systems with inaccessible outputs. A case in which dynamical system outputs cannot be measured or inaccessible.
Celebi, Besir   +8 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

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