Results 51 to 60 of about 292,252 (254)

Direct Data-Driven Portfolio Optimization with Guaranteed Shortfall Probability [PDF]

, 2013
This paper proposes a novel methodology for optimal allocation of a portfolio of risky financial assets. Most existing methods that aim at compromising between portfolio performance (e.g., expected return) and its risk (e.g., volatility or shortfall ...
Bawa, Ben-Tal, Bertsimas, Bertsimas, Calafiore, Calafiore, Calafiore, Campbell, Campi, Campi, Chen, Chopra, Delage, El Ghaoui, Giuseppe Carlo Calafiore, Goldfarb, Jabbour, Jorion, Lobo, Rachev, Ruppert, Shleifer, Zymler   +22 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Gene expression programming approach to event selection in high energy physics [PDF]

, 2006
Gene Expression Programming is a new evolutionary algorithm that overcomes many limitations of the more established Genetic Algorithms and Genetic Programming. Its first application to high energy physics data analysis is presented.
Teodorescu, L
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Tail Risk Constraints and Maximum Entropy

Entropy, 2015
Portfolio selection in the financial literature has essentially been analyzed under two central assumptions: full knowledge of the joint probability distribution of the returns of the securities that will comprise the target portfolio; and investors ...
Donald Geman, Hélyette Geman, Nassim Nicholas Taleb   +2 more
doaj   +1 more source

Mean-tail Gini Framework for Optimal Portfolio Selection

26 pages, 2 figures and 7 ...
Chen, Jinghui, Furman, Edward, Ricci, Stephano, Shanthirajah, Judeto   +3 more
openaire   +2 more sources

The heavy quark search at the LHC

, 2007
We explore further the discovery potential for heavy quarks at the LHC, with emphasis on the $t'$ and $b'$ of a sequential fourth family associated with electroweak symmetry breaking.
ATLAS TDR, B. Holdom, B. Holdom, Bob Holdom, F. Maltoni, G. Corcella ., G. Corcella ., J. Conway, M.L. Mangano, M.L. Mangano, M.S. Chanowitz, P. Savard, P. Skands, S. Frixione, S. Frixione, T. Sjostrand, TeV4LHC QCD Working Group collaboration   +16 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin

Frontiers in Immunology
IntroductionAutoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies.
Ke Liu, Pei Zhang, Zi-Shan Jin, Xiang-Kun Meng, Jin-Li Luo, Jin-Li Luo, Jin-Li Luo, Lin Han, Xiao-Tong Yu   +8 more
doaj   +1 more source

Optimal selection of sampling filter membranes for alpha radioactive aerosols based on spectrum tailing and detection efficiency tests

He jishu, 2021
BackgroundSampling filter membrane is an important part of the continuous monitoring system for radioactive aerosols. The performance of the sampling filter membrane directly affects detection efficiency of the system. In addition, tailing effect in α spectra increases the difficulty of identifying nuclides, reduces the accuracy of aerosol measurement,
ZHANG Junxin, GU Yi, WAN Qianyin, LIU Qiushi, LIN Wenzhao   +4 more
openaire   +1 more source