Results 131 to 140 of about 61,559 (268)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Proximal Policy Optimization for Efficient D2D-Assisted Computation Offloading and Resource Allocation in Multi-Access Edge Computing

Future Internet
In the advanced 5G and beyond networks, multi-access edge computing (MEC) is increasingly recognized as a promising technology, offering the dual advantages of reducing energy utilization in cloud data centers while catering to the demands for ...
Chen Zhang, Celimuge Wu, Min Lin, Yangfei Lin, William Liu   +4 more
doaj   +1 more source

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Advanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, Heping Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen   +15 more
wiley   +1 more source

Do the ECB and the Fed really need to cooperate? Optimal monetary policy in a two-country world.

A two-country model with monopolistic competition and price stickiness is employed to investigate the implications for macroeconomic stability and the welfare properties of three international policy arrangements: (a) cooperative, (b) non-cooperative and
Pappa, Evi
core  

Openness, imperfect exchange rate pass-through and monetary policy. NBB Working Paper Nr. 19 [PDF]

, 2002
This paper analyses the implications of imperfect exchange rate passthrough for optimal monetary policy in a linearised open-economy dynamic general equilibrium model calibrated to euro area data.
Wouters, Raf, Smets, Frank
core  

Architecture‐Controlled Hierarchical Carbon‐Based Current Collector for Mitigating Interfacial Instabilities in Lithium‐Metal Anodes

Advanced Science, EarlyView.
A defect‐engineered, hierarchically porous carbon black/CNT current collector guides lithiophilic nucleation in 3D architecture. Steam‐created defects enable uniform Li plating, while CNTs provide conductivity and a lightweight framework, suppressing dendrites and side reactions for stable anode‐free cells.
Seo Hui Kang, Dong Hyeon Hwa, Ji Su Chae, Kwang Chul Roh   +3 more
wiley   +1 more source

Optimal Technology Choice and Investment Timing: A Stochastic Model of Industrial Cogeneration vs. Heat-Only Production [PDF]

In this paper we develop an economic model that explains the decision-making problem under uncertainty of an industrial firm that wants to invest in a process technology.
Reinhard Madlener, Marcel Wickart
core  

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Scoping review of needs for digital technology in co-creation: a health CASCADE study

Research Involvement and Engagement
Background Patient and public involvement (PPI) is increasingly recognised as essential for meaningful, equitable, and impactful health and social care research. Co-creation is a promising involvement approach, but it faces barriers to enable its optimal
Quentin E. A. Loisel, Qingfan An, Vinayak Anand-Kumar, George Balaskas, Homer Papadopoulos, Dimitra Pappa, Maria Giné-Garriga, Giuliana Raffaella Longworth, Sebastien F. M. Chastin   +8 more
doaj   +1 more source