Results 131 to 140 of about 1,379,735 (279)
Hybrid Wasserstein Distance: An Approximation for Optimal Transport Distances
ComputationProjection-based variants of optimal transport, such as the Sliced Wasserstein (SW) and its extensions, have become popular alternatives to classical Wasserstein distances due to their scalability and analytical tractability.
Sara Nassar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A Mathematical Framework for Modeling Global Value Chain Networks
FoundationsGlobal value chains (GVCs) have evolved into highly interconnected and geographically fragmented production networks, increasing exposure to systemic disruptions and revealing the limitations of static input–output and conventional network approaches ...
Georgios Angelidis
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Extraction of implicit field cost via inverse optimal Schrödinger bridge
SICE Journal of Control, Measurement, and System IntegrationPath planning and navigation are typically conducted based on a field cost defined over a given space. However, determining an appropriate field cost is challenging. Animals, including humans, act based on past experience.
Koshi Oishi +3 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Multimodal Fake News Detection with Contrastive Learning and Optimal Transport
Frontiers in Computer ScienceIntroductionThe proliferation of social media platforms has facilitated the spread of fake news, posing significant risks to public perception and societal stability.
Xiaorong Shen +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source