Results 131 to 140 of about 1,392,762 (281)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Frontiers in OncologyBackground and objectiveAccurate prostate cancer risk stratification benefits from the fusion of T2-weighted (T2WI) and Apparent Diffusion Coefficient (ADC) MRI.
Hanying Gong +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hybrid Wasserstein Distance: An Approximation for Optimal Transport Distances
ComputationProjection-based variants of optimal transport, such as the Sliced Wasserstein (SW) and its extensions, have become popular alternatives to classical Wasserstein distances due to their scalability and analytical tractability.
Sara Nassar +2 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
A Mathematical Framework for Modeling Global Value Chain Networks
FoundationsGlobal value chains (GVCs) have evolved into highly interconnected and geographically fragmented production networks, increasing exposure to systemic disruptions and revealing the limitations of static input–output and conventional network approaches ...
Georgios Angelidis
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Dual-Graph Multimodal Named Entity Recognition With Optimal Transport Fusion
IEEE AccessMultimodal Named Entity Recognition (MNER) aims to leverage both textual and visual information to perform entity recognition and classification tasks collaboratively, holding significant application value in scenarios such as social media.
Shihong Wu, Yupeng Ma, Ming Zhang
doaj +1 more source
Linearized Optimal Transport on Manifolds
SIAM Journal on Mathematical Analysis45 pages, 10 figures Numerical examples can be generated using the code at https://gitlab.gwdg.de/bernhard.schmitzer ...
Clément Sarrazin, Bernhard Schmitzer
openaire +4 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source