Results 141 to 150 of about 90,500 (318)
Efficient coding in biophysically realistic excitatory-inhibitory spiking networks
eLifeThe principle of efficient coding posits that sensory cortical networks are designed to encode maximal sensory information with minimal metabolic cost.
Veronika Koren +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2004 The argument that I tried to elaborate on in this paper is that the conceptual problem behind the traditional competence/performance distinction does not go away, even if we abandon its original Chomskyan formulation. It returns as the question about the
Vogel, Ralf
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
On the Equivalence of Optimality Design Criteria for the Placebo-Treatment Problem [PDF]
We consider a class of optimality criteria and show that each crite- rion has its unique and equivalent dual within the class. This property can be used to find a variety of optimal designs, including a class of compound optimal designs and their ...
Zhu, Wei, Dette, Holger, Wong, Weng Kee
core
Parallelism and Planes in Optimality Theory: Evidence from Afar
, 1997 In this dissertation I show that the representations in Optimality Theory must be extended to allow multiple planes. The variable-position affixes in Afar occur as either prefixes or suffixes depending on the initial segment of the verb root. If the root
Fulmer, Sandra Lee
core +1 more source
Discounting Water for Optimal Carbon Gain as a Basis of Stomatal Closure
AGU AdvancesThe exchange of carbon dioxide and water vapor between terrestrial ecosystems and the atmosphere is regulated by stomata (small pores in the leaves of plants).
Mazen Nakad
doaj +1 more source
GOVERNMENT INVOLVEMENT IN CONSUMPTION BEHAVIOUR [PDF]
Annals of the University of Petrosani: Economics, 2010 In this article, we will follow the involvement that the government has,through its expenses, on the consumption behavior. The involvement that the government has inthe consumption behavior is made through fees and taxes that are applied on income.
CRISTINA ZAMFIR +2 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source