Results 81 to 90 of about 2,528,480 (312)
On optimality in intergenerational risk sharing [PDF]
This paper defines and studies optimality in a dynamic stochastic economy with finitely lived agents, and investigates the optimality properties of an equilibrium with or without sequentially complete markets.
Gabrielle Demange
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
English stress preservation and Stratal Optimality Theory [PDF]
, 2007 Since Chomsky & Halle (1968), English stress preservation has been important in generative discussions of morphophonological interaction. This thesis carries out empirical investigations into English stress preservation, and uses their results to argue ...
Collie, Sarah
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Evaluating the complexity of optimality theory
, 2009 Idsardi (2006) claims that Optimality Theory (OT; Prince and Smolensky (1993/2004) is "in general computationally intractable" on the basis of a proof adapted from Eisner (1997). We take issue with this conclusion on two grounds.
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
mic Efficiency and Pareto Optimality in a Stochastic OLG Model with Production and Social Security [PDF]
We analyze the interaction between risk sharing and capital accumulation in a stochastic OLG model with production. We give a complete characterization of interim Pareto optimality.
Marcus Hagedorn +2 more
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An Optimality Theoretic Approach to Navajo Prefixal Syllables
, 1998 An Optimality Theoretic Approach to Navajo Prefixal Syllables Amy V. Fountain University of Arizona Navajo is a Southern Athapaskan language spoken by approximately 160,000 people in Arizona and New Mexico.
Fountain, Amy Velita
core +1 more source
Degraded acceptability and markedness in syntax, and the stochastic interpretation of optimality theory [PDF]
, 2004 The argument that I tried to elaborate on in this paper is that the conceptual problem behind the traditional competence/performance distinction does not go away, even if we abandon its original Chomskyan formulation. It returns as the question about the
Vogel, Ralf
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source