Results 101 to 110 of about 2,528,480 (312)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Typology of Rounding Harmony: An Optimality Theoretic Approach
, 1995 This thesis explores the typology of rounding harmony within the framework of optimality theory. A systematic survey of the range of attested rounding harmony phenomena is presented and an analysis of this typology is proposed which invokes constraints ...
Kaun, Abigail Rhoades
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Non-computable functions in Optimality Theory
, 1999 Is Optimality Theory a constraining theory? A formal analysis shows that it is, if two auxiliary assumptions are made: (1) that only markedness and faithfulness constraints are allowed, and (2) that input and output representations are made from the same
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Deterministic Impulse Control Maximum Principle in Operations Research: Necessary and Sufficient Optimality Conditions (replaces CentER DP 2011-052) [PDF]
This paper considers a class of optimal control problems that allows jumps in the state variable. We present the necessary optimality conditions of the Impulse Control Maximum Principle based on the current value formulation.
Chahim, M., Hartl, R.F., Kort, P.M.
core
Optimality Theory: Constraint Interaction in Generative Grammar
, 2002 This work develops a conception of grammar in which optimality with respect to a set of constraints defines well-formedness. The argument begins with a brief assessment of the promise of optimization-based approaches, focusing on issues of explanation ...
core +1 more source
, 2003 A construction algorithm for multioutput radial basis function (RBF) network modelling is introduced by combining a locally regularised orthogonal least squares (LROLS) model selection with a D-optimality experimental design.
Harris, C. J. +3 more
core +2 more sources
Shanghai Jiaotong Daxue xuebaoExisting parameter design for power forecasting in park integrated energy systems (PIESs) focuses on minimizing the forecasting error of either source or load power, aiming at obtaining prediction results closest to the actual power without considering ...
LIU Songyuan, FAN Feilong, PU Chuanqing, DOU Zhenlan, ZHANG Chunyan, CHEN Hongyin
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source