Results 121 to 130 of about 2,528,480 (312)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Prosodic domains and ambisyllabicity in optimality theory
, 1997 Selkirk 1984, 1986, Nespor & Vogel 1986 and others independently argue that PrWd structure is built from morphological structure. In Optimality Theory, Generalized Alignment (McCarthy & Prince 1993b) has been successful in encoding the close relationship
Hong, Soonhyun
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Optimality Theory and the Minimalist Program
, 2006 In this paper I argue that an OT-approach to grammar is actually essential to minimalist investigations, because it dramatically widens the set of linguistic properties potentially reducible to interface conditions while at the same time dispensing with ...
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
English loanwords in Thai and Optimality Theory
, 2007 This study focuses on English loanwords in Thai, particularly the treatment of consonants in different environments, namely onset/coda simplification, laryngeal features, medial consonants, and liquid alternation, within the framework of Optimality ...
core
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
On the Equivalence of Optimality Design Criteria for the Placebo-Treatment Problem [PDF]
We consider a class of optimality criteria and show that each crite- rion has its unique and equivalent dual within the class. This property can be used to find a variety of optimal designs, including a class of compound optimal designs and their ...
Zhu, Wei, Dette, Holger, Wong, Weng Kee
core
Projection-Based Optimal Control for Nonlinear Systems with Direction-Dependent Inputs
MathematicsThis paper investigates a class of nonlinear optimal control problems in which the effectiveness of the control input depends not only on its magnitude, but also on its directional alignment with the instantaneous system evolution.
Chan Roh
doaj +1 more source