Results 111 to 120 of about 23,247 (311)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A bidirectional Optimality Theoretic analysis of multiple negative indefinites in Afrikaans
Stellenbosch Papers in Linguistics, 2014 In the literature on negation, Afrikaans is generally categorised as a negative concord language. Unlike most other negative concord languages though, utterances containing multiple indefinites in the scope of negation are typically produced with a ...
Huddlestone, Kate, de Swart, Henriëtte
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Combining Optimality Theory and a Cognitive Architecture [PDF]
, 2003 Optimality Theory (OT) has had a lot of attention from the linguistics research community but also still largely lacks cognitive grounding. We used the ACT-R cognitive architecture to gain greater insight into the cognitive grounding issues that OT needs
core
Optimality Theory and language death [PDF]
, 2010 This paper exposes a gap in the literature regarding studies that use an optimality-theoretic framework to examine phonological variation in endangered language varieties. It shows that dying languages, characterized by inter- and intra-speaker variation
Darcie Blainey
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Wh-Islands: A View from Correspondence Theory [PDF]
, 2007 This paper discusses a family of restrictions on syntactic extraction, so-called wh-islands. The analysis will be based on the OT syntax model developed in Vogel (2004a,b) which focuses on the correspondence between semantic, syntactic and phonological ...
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Zeitschrift für Sprachwissenschaft, 2008 In this article, I propose a new family of constraints on affix order, called “Coherence”, which require that index changes in morphological words are minimized. Coherence constraints complement the optimality-theoretic account of affix order for subject
Trommer Jochen
doaj +1 more source