Results 181 to 190 of about 933,480 (358)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Toward intelligent IoT scheduling with quantum-inspired latent models for energy and latency optimization. [PDF]

Sci Rep
Alyas T, Abbas Q, Hayat A, Nawaz W, Alshanqiti A, Almoamari H, Ibrahim AM.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Quantitative Lateral Flow Assay for Meropenem Determination: A Proof-of-Concept Study

ACS Omega
Vasin Vasikasin, Alaa Riezk, Richard C. Wilson, Timothy M. Rawson, Anthony E.G. Cass, Alison H. Holmes   +5 more
doaj   +1 more source

Selective Reinforcement Optimization for Composite Laminates. [PDF]

Materials (Basel)
Balashov A, Burduk A, Krzysztoporski M, Kotowski P.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The impact of dose rate optimisation and robust optimisation on FLASH proton therapy treatment plan quality and dose rates. [PDF]

Front Oncol
Lövgren N, Nilsson R, Traneus E, Petersson K.   +3 more
europepmc   +1 more source

L'impact de l'audit social sur le climat social des entreprises pour une optimisation de la performance sociale au travail : cas des entreprises au Maroc

, 2022
SEKAKI Yassine, ZAAM Houria
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Smart scheduling of arthroplasty surgery with machine learning and optimisation improves operating room utilisation. [PDF]

BMJ Health Care Inform
Lex JR, Abbas A, Toor JS, Khalil EB, Ravi B, Whyne CM.   +5 more
europepmc   +1 more source