Results 191 to 200 of about 690,038 (285)

Accelerating cancer treatment optimisation: A multistakeholder roadmap from the Cancer Medicines Forum.

J Cancer Policy
Lacombe D, Cardoso Borges F, Amariutei AE, Booth CM, Brusselle G, Casolino R, Demolis P, Giuliani R, Goldstein DA, Gravis G, Kaiser M, Korakis I, Radulovic M, Sullivan R, Tombal B, Wieseler B, Zaiac M, Voltz-Girolt C, Pignatti F.   +18 more
europepmc   +1 more source

Hollow Auxetic Polymer Structures with Manufacturing-Constrained Design and Mechanical Validation. [PDF]

Polymers (Basel)
Bridge F, Albarakati R, Hassanin H, Essa K.   +3 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Optimization of protein extraction and digestion workflows for proteomic analysis of saliva, salivary stones and kidney stones. [PDF]

Front Mol Biosci
Musiał N, Iwaniec M, Mruk I, Puchalski M, Tretiakow D, Skorek A, Szydłowski K, Szlęzak J, Czaplewska P.   +8 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Selective Reinforcement Optimization for Composite Laminates. [PDF]

Materials (Basel)
Balashov A, Burduk A, Krzysztoporski M, Kotowski P.   +3 more
europepmc   +1 more source

Optimisation

FLEscape, 2018
openaire   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Optimisation of a Caprylic Acid-Based Protocol for IgG Purification from Baboon (<i>Papio anubis</i>) Serum. [PDF]

Methods Protoc
Ogopotse W, Musabyimana V, Khasandi PM, Kotti D, Ngotho M, Kagira JM, Oluoch GO.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source