Results 131 to 140 of about 11,261,256 (335)
A comprehensive study on modern optimization techniques for engineering applications
Artificial Intelligence ReviewRapid industrialization has fueled the need for effective optimization solutions, which has led to the widespread use of meta-heuristic algorithms. Among the repertoire of over 600, over 300 new methodologies have been developed in the last ten years ...
Shitharth Selvarajan
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Post-stenting optimisation techniques in bifurcation percutaneous coronary interventions: much remains to be explored. [PDF]
EuroIntervention, 2021 Chieffo A, Beneduce A.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Optimal design of wind turbine blades equipped with flaps [PDF]
, 2014 As a result of the significant growth of wind turbines in size, blade load control has become the main challenge for large wind turbines. Many advanced techniques have been investigated aiming at developing control devices to ease blade loading.
Maheri, Alireza, Wiratama, I. Kade
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Optimising Graphical Techniques Applied to Irreversible Tracers
Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies, 2018 Graphical analysis techniques are often applied to positron emission tomography (PET) images to estimate\ud physiological parameters. Patlak analysis is primarily used to obtain the rate constant (Ki) that indicates the\ud transfer of a tracer from plasma to the irreversible compartment and ultimately describes how the tracer\ud binds to the targeted ...
Alzamil, Yasser +3 more
openaire +1 more source