Results 71 to 80 of about 2,429,878 (317)
Stress-constrained topology optimization using the constrained natural element method [PDF]
This paper presents a topology optimization framework to achieve volume minimization with Crossland fatigue constraints under proportional loading using the Constrained Natural Element Method.
CHEN, Yanda +4 more
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Optimizing Bayesian optimization
, 2018 We are concerned primarily with improving the practical applicability of Bayesian optimization. We make contributions in three key areas. We develop an intuitive online stopping criterion, allowing only as many steps as necessary to achieve the desired target to be taken. By combining this with intelligent online switching between acquisition functions
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Testing approaches for global optimization of space trajectories [PDF]
, 2008 In this paper the procedures to test global search algorithms applied to space trajectory design problems are discussed. Furthermore, a number of performance indexes that can be used to evaluate the effectiveness of the tested algorithms are presented.
Vasile, M. +7 more
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Optimization Library for Interactive Multi-Criteria Optimization Tasks
, 2012 The commercial library Optimization 2.1 for interactive multi-criteria optimization tasks has been released along with Dymola 2013. The library offers several numerical optimization algorithms for solving different kinds of optimization tasks.
Pfeiffer, Andreas, Andreas Pfeiffer
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Scientific ReportsHepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology.
Isis Narváez-Bandera +6 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Optimization Algorithms - Classics and Last Advances is devoted to developing algorithm theory and exploring the use of different optimization algorithms for solving various problems in pure science, applied physics, and information technology.
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Equating κ Maximum Degrees in Graphs without Short Cycles
Discussiones Mathematicae Graph Theory, 2020 For an integer k at least 2, and a graph G, let fk(G) be the minimum cardinality of a set X of vertices of G such that G − X has either k vertices of maximum degree or order less than k.
Fürst Maximilian +4 more
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When is Assortment Optimization Optimal?
Proceedings of the 23rd ACM Conference on Economics and Computation, 2022 Assortment optimization concerns the problem of selling items with fixed prices to a buyer who will purchase at most one. Typically, retailers select a subset of items, corresponding to an “assortment” of brands to carry, and make each selected item available for purchase at its brand-recommended price.
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